A method for detecting, in single time-point, in-vivo imaging data related to artifacts in the imaging of objects, includes acquiring at least one in-vivo image with imaging apparatus. A background image corresponds to imaged air of the in-vivo image. The background image is obtained in two steps. A first step includes establishing an object-air boundary and a second step is an atlas-based refinement of a background volume of interest. A histogram reflects an intensity distribution of the background image. The background image is formed of a set of voxels where artifacts are detected. Intensities above a definable intensity value provide an initial estimate of a range of artifacts intensities. A modified morphological opening operation is executed, formed of an erosion of a set of voxels and a dilation, performed iteratively and constrained to voxels intensity above the intensity value, so that the opening operation provides natural definition of artifacts regions.