Methods and apparatus are provided for generating a color profile for a color output device including a plurality of colorants, the methods and apparatus printing a plurality of color patches on an output medium, measuring a spectral or colorimetric response for each of the printed patches and for the output medium, calculating spectral or colorimetric responses for overprint combinations of the colorants based on the measured spectral or colorimetric responses, calculating colorimetric values in a profiling target based on the calculated and measured responses, and providing the calculated colorimetric values to profiling software for generation of the color profile.