The present invention relates to novel methods and compositions for
detection and isolation of cancer cells with metastatic potential. The
invention further relates to assays for measuring the metastatic
potential of such cancer cells and drug screening assays for the
identification of agents having anti-metastatic potential. The present
invention further provides methods and compositions for inhibiting the
metastatic potential of cancer cells by modulating the activity of serine
integral membrane proteases [(SIMP) consisting of seprase and dipetidyl
peptidase IV (DPPIV)] expressed on the surface of metastasizing cancer
cells.