Methods and systems for producing customized dental restoration and prosthesis, particularly denture prescriptions using a computer software program are provided. In this system, digital photographs of the patient to be fitted with the denture are taken, and the photographs are transferred to the software program. Based on these photographs, the program makes certain calculations. The program then prompts the dental professional to select the desired materials and structure for the denture. Based on this input, the program automatically produces a prescription for the denture. The digital prescription is sent to a dental laboratory for making the denture.