Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 protease that comprise a compound comprising the formula: ##STR00001## wherein Q is selected from the group of CO, SO, SO.sub.2, or C.dbd.NR.sub.9; and R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as defined herein.

 
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