The disclosure relates to a compound of formula (I): ##STR00001## wherein R, R2, R3, R4, R5, Z, W and D are as defined in the specification, to compositions containing them, to processes for preparing them, and to their use in the treatment or prevention of conditions capable of being modulated by the inhibition of the activity of protein kinases.

 
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> NOVEL ALKYL SUBSTITUTED PIPERIDINE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS

> 4-((PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS

~ 00589