Approaches for estimating capture thresholds for alternate pacing vectors of multi-electrode pacing devices are described. Capture thresholds of at least one initial pacing vector is measured. The impedance of the initial pacing vector and at least one alternate pacing vector is measured. The initial and alternate pacing vectors have an electrode in common. The common electrode has the same polarity in both the initial and the alternate pacing vectors. The capture threshold for the alternate pacing vector may be estimated based on the measured capture threshold of the initial pacing vector, the measured the impedance of the initial pacing vector, and the measured impedance of the alternate pacing vector.

 
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