We propose a class of mechanisms to support a new style of synchronization that offers simple and efficient solutions to several existing problems for which existing solutions are complicated, expensive, and/or otherwise inadequate. In general, the proposed mechanisms allow a program to read from a first memory location (called the "flagged" location), and to then continue execution, storing values to zero or more other memory locations such that these stores take effect (i.e., become visible in the memory system) only while the flagged memory location does not change. In some embodiments, the mechanisms further allow the program to determine when the first memory location has changed. We call the proposed mechanisms conditional multi-store synchronization mechanisms and define aspects of an instruction set architecture consistent therewith.