The liquid composition is based on surfactants and enzymes, and is particularly useful for manual cleaning of instruments. In manual and ultrasonic application the composition in use concentration shows low foaming and gives a cleaning solution which is not cloudy at least at a temperature in the range from 16.degree. C. to 40.degree. C. In addition, the composition has good cleaning efficacy over a broad temperature range (20 to 55.degree. C.) and shows good material compatibility.