A method of diagnosing a disease or syndrome associated with disregulation
of Neuregulin-4 (NRG-4), Aa novel ErbB-4 ligand, referred to herein as
Neuregulin-4 (NRG-4)in a subject is disclosed. The method comprising: (a)
obtaining a sample from a subject; (b) incubating the sample with at
least one oligonucleotide or oligonucleotide analog of at least bases,
said oligonucleotide or oligonucleotide analog capable of hybridizing to
a portion of a polynucleotide strand encoding NRG-4 to thereby diagnosing
the disease, condition or syndrome associated with disregulation of
NRG-4.