Multi-drop closure systems for fiber optic cabling include an enclosure and a ganged drop plug. The enclosure defines a splice chamber therein and has a main cable access opening and a drop cable access opening into the splice chamber. The drop cable access opening is displaced from the main cable access opening. The ganged drop plug is configured to be sealingly inserted into the drop cable access opening. The ganged drop plug has a plurality of drop cables extending therefrom.