A method of tracking and processing at least one cargo container having an indefinite security status (ISS). In one embodiment, the method of the present invention comprises: (A) detecting at least one statistically significant threat (SST) signal associated with at least one cargo container while in transit; (B) if at least one such SST signal was detected, identifying each cargo container that generated at least one such SST signal and classifying the security status of each such cargo container as a Potential Threat (PT) cargo container; (C) substantially continuously checking at least one generated SST signal to verify the security status of at least one PT container while in transit; (D) if at least one SST signal is confirmed to be a false positive SST signal, changing the security status of at least one PT container associated with the false positive SST signal to an indefinite security status (ISS) cargo container; and (E) tracking and reporting position coordinates and security status of each ISS PT cargo container to an appropriate party.