The present invention provides adeno-associated virus (AAV) materials and methods which are useful for DNA delivery to cells. More particularly, the invention provides recombinant AAV (rAAV) genomes, methods for packaging rAAV genomes, stable host cell lines producing rAAV and methods for delivering genes of interest to cells utilizing the rAAV. Particularly disclosed are rAAV useful in generating immunity to human immunodeficiency virus-1 and in therapeutic gene delivery for treatment of neurological disorders.

 
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< Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site

> Low-toxicity, long-circulating human interferon-alpha PEGylated mutants

> Respiratory syncytial virus vaccines expressing protective antigens from promoter-proximal genes

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