The present invention discloses a device with a lens-rotation mechanism, which comprises: a casing having a driving device, such as the casing of a camera, a mobile phone or a video camera; and a lens-rotation system installed to the casing and having at least two transmission elements. Those two transmission elements are respectively coupled to the driving device and driven by the driving device to move horizontally and vertically, and those two transmission elements further drive the lens-rotation system to rotate. Thereby, the device with a lens-rotation mechanism proposed by the present invention can control the rotation of a lens.