Disclosed is a system for and a method of registering images captured by a
computer-controlled microscope. The imaging system of the present
invention includes a computer-controlled microscope electrically
connected to a controller having a display device. The microscope further
includes a barcode reader, a camera, a serial interface, one or more
sensors, one or more motors, a light source, a turret, and a data
interface. The method of image registration includes the steps of
defining areas of interest on a microscope slide, creating a database of
microscopic image locations, commanding a microscope to each location,
capturing and storing an image, calculating correlation with neighbors,
registering correlation scores and offsets, determining an anchor, and
attaching neighbors using correlation scores and offsets.