The present invention provides compounds, methods and systems for sequencing nucleic acid using single molecule detection. Using labeled NPs that exhibit charge-switching behavior, single-molecule DNA sequencing in a microchannel sorting system is realized. In operation, sequencing products are detected enabling real-time sequencing as successive detectable moieties flow through a detection channel. By electrically sorting charged molecules, the cleaved product molecules are detected in isolation without interference from unincorporated NPs and without illuminating the polymerase-DNA complex.

 
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> Nucleic acids encoding a galacturonosyl tranferase enzyme (GALAT1) from arabidopsis

> Db, the receptor for leptin, nucleic acids encoding the receptor, and uses thereof

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