A group of novel phenanthroindolizidine alkaloid compounds as shown and their use in treating cancer. Also disclosed are methods of using phenanthroindolizidine alkoid compounds in suppressing NO and TNF-.alpha. production, inhibiting MEKK1 activity and cyclooxygenase II expression, and treating NO-related disorders.

 
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> Cyclic ureas used as inhibitors of metalloproteases

> Methods of using (+)-2-[1-(3-ethoxy-4 methoxyphenyl)-2-methylsulfonylethyl]-4 acetylaminoisoindoline 1,3-dione
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