An oral pharmaceutical composition for targeted transport of a platinum
complex into the colorectal region, includes a mixture of platinum
complex of general formula I ##STR00001## wherein A each independently
is an --NH.sub.3 group or an amino group containing 1 to 18 carbon atoms,
B each independently is a halogen atom, a hydroxy group or a --O--C(O)--R
group wherein R each independently is hydrogen atom or an alkyl, alkenyl,
aryl, aralkyl, alkylamino or alkoxy group containing 1 to 10 carbon atoms
or functional derivatives of these groups, and X each independently is a
halogen atom or a monocarboxylate group containing 1 to 20 carbon atoms,
or X together form a dicarboxylate group containing 2 to 20 carbon atoms,
and at least one excipient selected from the group including a
saccharide, oligosaccharide, polysaccharide, modified polysaccharide
mucopolysaccharide, protein, oligoprotein, polyprotein, mucoprotein,
peptide, oligopeptide and polypeptide, and optionally a lubricant and/or
disintegrant, which mixture is optionally compressed into a tablet or
contained in a capsule, and this tablet or capsule is optionally coated
with a biodegradable layer and/or an outer pH-sensitive colonic layer,
and a method of manufacturing and using the composition for treatment of
colorectal carcinoma.