As prophylactic and/or therapeutic agents for cardiovascular diseases, bone or joint diseases, infectious diseases, inflammatory diseases, kidney diseases, etc. having safe and excellent effects of cell death inhibition, MIF binding, etc., there are provided compounds represented by formula: ##STR00001## [wherein, R.sup.1 represents a halogen atom, etc., R.sup.2 represents a group represented by formula: ##STR00002## (wherein, R.sup.3 represents hydrogen atom, an optionally substituted alkoxy, etc., R.sup.4 represents hydrogen atom, bromine atom, cyano, etc., R.sup.5 represents hydrogen atom, hydroxy, etc., R.sup.6 represents hydrogen atom, etc., R.sup.7 represents hydrogen atom, etc.) etc., and n represents an integer of 0 to 4] or salts thereof.