The present invention provides compounds of formula I: ##STR00001## wherein R.sup.1 is an alkyl, phenyl, heterocyclyl, cycloalkyl, alkoxy, ester, amino or amide group; R.sup.2 is a phenyl, heterocyclyl, alkyl, cycloalkyl or cycloalkylalkyl group; R.sup.3 is an alkyl, cycloalkyl, cycloalkylalkyl, amino or heterocyclyl group; R.sup.4 and R.sup.5 are hydrogen or alkyl or form a cycloalkyl ring; A is O or N; and m is zero or one;as inhibitors of GlyT1 and thus as useful for treating or preventing diseases such as schizophrenia; with the provision of pharmaceutical compositions, first and second medical uses and methods of treatment.

 
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