A multi-layered, absorbent perineal pad is disclosed that has a generally ovate cross-section. In disclosed embodiments, the pad has an absorbent outer layer, antimicrobial intermediate layer, and absorbent inner layer. At least two opposing edges of the pad are sealed to one another so that the absorbent inner layer encloses an internal cavity within the pad. The pad may be used to absorb liquids from perineal structures (such as vaginal or anal liquids) or administer agents to perineal structures. Liquids that are absorbed in the pad can be subjected to diagnostic assays.