Provided are a method, system, and article of manufacture for managing encryption for volumes in storage pools. At least one storage pool is defined in a database, wherein storage pools are defined to include a plurality of data volumes, wherein each volume is included in at least one storage media. An encryption status is indicated for storage pools indicating whether encryption is enabled for the storage pool. An encryption key is provided for volumes included in storage pools for which encryption is indicated as enabled. The encryption keys for volumes included in the storage pools for which encryption is enabled are stored. The database associates the encryption keys with the volumes and the volumes with the storage pools.