Practice barrels for use with practice cartridges are described herein. An example practice device for use with self-loading grenade launchers includes a practice barrel having a practice cartridge chamber to receive a practice cartridge. A live cartridge does not correspond to the practice cartridge chamber. Additionally, the live cartridge is unable to be properly positioned within the practice barrel to prevent ignition of the live cartridge. Further, the practice cartridge chamber is cushioned to substantially absorb a breech energy to substantially prevent damage to the practice barrel.