The present invention relates to novel coordination complexes, methods for synthesizing and identifying coordination complexes, using combinatorial techniques, and assaying their activity. In certain embodiments, the invention relates to a library comprising a plurality of platinum-containing coordination complexes represented by the general formula {PtL.sub.nA.sub.(4-n)}, wherein, independently for each occurrence, each L is a non-labile ligand under standard conditions, each n is equal to 1, 2 or 3; each A is a labile ligand under standard conditions; and each Pt is Pt(II) or Pt(IV); provided that when Pt is Pt(IV), two additional ligands in the trans axial positions of the general formula depicted are present; and at least one of the plurality of platinum-containing coordination complexes is represented by the formula ##STR00001## wherein, independently for each occurrence: X represents halogen or other labile ligand under standard conditions; W represents S, N, or P; Y represents --OR7, --SR7, a halogen or --N(R9)R10; R9 and R10, each independently, represent --H, alkyl, alkenyl, --(CH.sub.2).sub.n--R7, or R9 and R10, taken together with the N atom to which they are attached complete a heterocycle having from 4 to about 8 atoms in the ring structure, all optionally substituted; L represents a non-labile ligand under standard conditions; R7 represents --H, alkyl, aryl, cycloalkyl, cycloalkenyl, heterocycle or polycycle; the ligand V comprises W, Y, and a heterocycle having from 4 to about 8 atoms in the ring structure, optionally aromatic and optionally substituted; and the symbol ##STR00002## represents a single or a double bond.