Compositions of modified cytokines and uses thereof generated using processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided are modified cytokines formulated for oral delivery and uses thereof to treat diseases and conditions mediated by cytokines.

 
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> PAAD domain-containing polypeptides, encoding nucleic acids, and methods of use

> Methods of increasing abiotic stress tolerance and/or biomass in plants
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