A reed mouthpiece for single reed woodwind musical instrument comprises a mouthpiece body defining an air passageway. A reed placement surface is defined on the mouthpiece body adjacent the air passageway. A reed retaining body is formed on the mouthpiece body for removably securing a reed to the mouthpiece includes first and second upstanding walls and a transverse portion extending therebetween. The reed retaining body and reed placement surface define an axially extending channel for receiving a heel end of the reed. The transverse portion includes a tapped opening rotatably receiving a threaded fastener. The threaded fastener may be selectively advanced toward the reed placement surface by rotating in one direction and retracted away from the reed placement surface by rotating in the opposite direction to allow selective engagement and disengagement of the reed. A shoulder is provided axially adjacent the reed placement surface to prevent passage of the reed completely through the axially extending channel.