Camera systems and methods with vibration compensation. The system comprises a first sensor, a second sensor, and a processing module. The first sensor detects an angle variation of a movement of a camera device to generate first sensed data. The second sensor detects a position movement of an image sensor of the camera device to generate second sensed data. The processing module takes the first derivative of the second sensed data, and calculates control information according to the first sensed data and the differential of the second sensed data. The processing module enables a drive device to adjust the position of the image sensor based on the control information.