A method and system for color calibration or color output device spectrophotoically measures at test target including a preselected test color value. A multi-dimensional LUT of the device is generated representative of the color information including the at least one preselected color. Producing a second image width device including the at least one preselected color located at a plurality of spatial locations in the second image. A second sensor measures the second image and a plurality of spatial locations having the preselected color for generating reflectance information for the preselected color at the plurality of spatial locations. An error is determined between the measured color of the one preselected color and the reflectance information at the other pixel locations. A multi-dimensional LUT is adjusted to minimize spatial uniformity errors at the other pixel locations, thus calibrating device color output spatially.