Disclosed herein are compounds, compositions and methods for modulating the expression of Mcl-1 in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.

 
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> Substrates of N-end rule ubiquitylation and methods for measuring the ubiquitylation of these substrates

> Compositions and methods for isolation, propagation, and differentiation of human stem cells and uses thereof

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