A facility is provided for managing register maps for map-based indirect register file access within a processor. The management facility includes a register mapping including a set of maps, each map of the set of maps having a plurality of map registers. A set of actual registers is indirectly accessed by the processor via map entries of the set of maps. The number of actual registers in the set of actual registers is greater than the number of map entries in the set of maps, and the map entries of the set of maps reference only a subset of the set of actual registers at any given time. The facility includes managing updates to multiple entries of the set of maps of the register mapping by updating multiple map entries of at least one map of the set of maps responsive to executing a single update instruction.