This invention concerns the compounds ##STR00001## the N-oxides, salts,
stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites
thereof, wherein X is NR.sup.2, O, S, SO, SO.sub.2; R.sup.1 is hydrogen,
cyano, halo, substituted carbonyl, methanimidamidyl,
N-hydroxy-methanimidamidyl, mono- or di(C.sub.1-4alkyl)methanimidamidyl,
Het.sub.1 or Het.sub.2; n is 1, 2 or 3; R.sup.2 is hydrogen, aryl
substituted with a radical --COOR.sup.4; or R.sup.2 is substituted
C.sub.1-10alkyl, C.sub.2-20alkenyl or C.sub.3-7cycloalkyl; or R.sub.2 is
a radical of formula: ##STR00002##
--C.sub.pH.sub.2p--CH(OR.sup.14)--C.sub.qH.sub.2q--R.sup.15 (b-3);
--CH.sub.2--CH.sub.2--(O--CH.sub.2--CH.sub.2).sub.m--OR.sup.14 (b-4);
--CH.sub.2--CH.sub.2--(O--CH.sub.2--CH.sub.2).sub.m--NR.sup.5aR.sup.5b
(b-5); -a.sup.1=a.sup.2-a.sup.3=a.sup.4- is --CH.dbd.CH--CH.dbd.CH--;
--N.dbd.CH--CH.dbd.CH--; --CH.dbd.N--CH.dbd.CH--;
--CH.dbd.CH--N.dbd.CH--; --CH.dbd.CH--CH.dbd.N-- (c-5); wherein one of
the hydrogen atoms in (c-1)-(c-5) is replaced by particular radicals;
R.sup.3 is nitro, cyano, amino, halo, hydroxy, C.sub.1-4alkyloxy,
hydroxycarbonyl, substituted carbonyl, methanimidamidyl, mono- or
di(C.sub.1-4alkyl)methanimidamidyl, N-hydroxy-methanimidamidyl or
Het.sub.1.
