A compound represented by the formula (I), a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof: ##STR00001## wherein X, Y, and W each independently represent a carbon atom or a nitrogen atom; Z represents CH or a nitrogen atom; R.sup.1 represents (1) C3-10 branched alkyl which may be substituted or (2) --(CH.sub.2).sub.m--NR.sup.4R.sup.5; R.sup.2 and R.sup.3 each independently represent (1) a hydrogen atom, (2) C1-4 alkyl which may be substituted with a halogen atom, hydroxy which may be protected, amino which may be protected, or carboxyl which may be protected, (3) C2-4 alkenyl, (4) C2-4 alkynyl, (5) nitrile, (6) COOR.sup.6, (7) CONR.sup.7R.sup.8, (8) COR.sup.101, (9) S(O).sub.nR.sup.102, or (10) a halogen atom, in which R.sup.6 represents a hydrogen atom or C1-4 alkyl, R.sup.7 and R.sup.8 each independently represent a hydrogen atom or C1-4 alkyl, R.sup.101 represents a hydrogen atom or C1-4 alkyl, R.sup.102 represents C1-4 alkyl, n represents 1 or 2; and Ar represents an aromatic ring which may be substituted, is useful as a pharmacologically active ingredient having a CRF antagonist action in preventing and/or treating neuropsychiatric diseases, diseases of peripheral organs or the like.