A pressure adjustment structure for a presser foot of a sewing machine, wherein one end of a horizontal arm of the sewing machine is disposed with a presser bar of the presser foot, and an elastic member is mounted on the presser bar. The end of the horizontal arm is provided with a main supporting frame, so that the pressing member slides on the main supporting frame with a pressing body and a guiding member, and one end of the pressing member presses an elastic member. In addition, the pressing body extends towards and is driven by an adjustment element of the main supporting frame, so that the pressing member driven by the pressing body slides on the main supporting frame to press the elastic member so as to provide different pressure. A second supporting frame is disposed on the main supporting frame to connect with the horizontal arm.