A topical antiviral composition comprising acyclovir, penciclovir and/or
omaciclovir in a glucocorticoid-free pharmaceutical carrier comprising 15
to 25 weight % propylene glycol and 10 to 25 weight % isopropyl
C.sub.12-C.sub.22 alkanoic ester. The compositions have utility in the
treatment or prophylaxis of herpesvirus infections. Clinical results
demonstrate that treatment commencing at the prodromal stage can prevent
the development of a classic cold sore lesion in a large proportion of
patients.