The present invention relates to HIV-1 envelope proteins from a donor with non-progressive HIV-1 infection whose serum contains broadly cross-reactive, primary virus neutralizing antibody. The invention also relates to isolated or purified proteins and protein fragments that share certain amino acids at particular positions with the foregoing HIV-1 proteins.

 
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> Synthetic nuclear localization signal derived from lentiviral integrase and methods of use thereof

> Engineering Fc Antibody regions to confer effector function
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