The present invention provides compounds having the formula: ##STR00001##
wherein R.sup.1, R.sup.2, X.sup.1, X.sup.2, L.sup.1, L.sup.2, Y and Z
are as defined in classes and subclasses herein, and pharmaceutical
compositions thereof, as described generally and in subclasses herein,
which compounds are useful as inhibitors of protein kinase (e.g.,
Aurora), and thus are useful, for example, for the treatment of Aurora
mediated diseases.