Systems and methods are described for implants with composite coatings to promote tissue in-growth and/or on-growth. An implant includes: a substrate; a structured surface formed on at least a portion of the substrate; and a biocompatible coating deposited on at least a fraction of the structured surface. The systems and methods provide advantages in that the implant has good biocompatibility while the biocompatible coating has good strength.

 
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> Coupled cofactor-dependent enzymatic reaction systems in aqueous media

> Compositions and methods for isolation, propagation, and differentiation of human stem cells and uses thereof

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