Compounds of the general formula (I) ##STR00001## are inhibitors of the reuptake of norepinephrine. As such, they may be useful for the treatment of disorders of the central and/or peripheral nervous system.

 
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< Chromosomal modification involving the induction of double-stranded DNA cleavage and homologous recombination at the cleavage site

> Beta-sulfonamide hydroxamic acid inhibitors of tace/matrix metalloproteinase

> Insulin expressing human pancreatic islet cell line capable of reversibly proliferating and use thereof
~ 00546