Compositions and uses of mGluR.sub.5 antagonists for the treatment and inhibition of amyloid precursor protein (APP), A.beta. protein, and APP proteolytic products in Alzheimer's disease, Fragile X Syndrome, autism, and Down's Syndrome are provided. The invention provides methods for diagnosing Fragile X Syndrome via the assessment of A.beta..sub.1-42 levels in blood plasma.

 
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