Formulations and methods for transmucosal delivery of a beneficial agent
are described in which a pH-responsive component and a
temperature-responsive component are combined and applied to a mucous
membrane. The temperature-responsive component is a component that, in
aqueous solutions, is capable of undergoing a temperature-dependent sol
to gel phase transition. The formulations may be characterized as having
bioadhesive properties, and are suitable for delivery of a variety of
beneficial agents.