The present invention discloses novel compounds of Formula I: having
11.beta.-HSD type 1 antagonist activity, as well as methods for preparing
such compounds. In another embodiment, the invention discloses
pharmaceutical compositions comprising compounds of Formula I, as well as
methods of using the compounds and compositions to treat diabetes,
hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome,
and other conditions associated with 11.beta.-HSD type 1 activity.
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