Immunogenic polypeptides having the capability to precipitate and focus a CpG adjuvant exhibit enhanced in vivo priming of a cytotoxic T-lymphocyte (CTL) response. Accordingly, compositions that include a bipartite immunogenic polypeptide are provided herein. The bipartite polypeptide includes a CpG-interacting amino acid sequence and a CTL-activating amino acid sequence. Also provided are methods of identifying and using a bipartite immunogenic polypeptide.