Applications, systems and methods for efficiently accessing and controlling data of devices among multiple computers over a network. Strategic cache management processes are provided to manage the data in cache memory of the storage devices involved. Communication of data over the network may be managed by means of one or more connection servers which may also manage any or all of authentication, authorization, security, encryption and point-to-multipoint communications functionalities. Alternatively, computers may be connected over a wide area network without a connection server, and with or without a VPN. Data transmissions may be managed to minimize bandwidth and may be temporally and/or spatially compressed.