Systems and methods for information compression. In a first method embodiment, a computer implemented method for compressing information includes finding a closest match entry of a dictionary to a data block, the dictionary stored in computer usable media. A logical exclusive OR combination of the closest match entry and the data block is performed to form a spatial difference vector identifying locations wherein the data block differs from the closest match entry. An information difference vector comprising differences between the data block and the closest match entry is formed. A compressed data block comprising the spatial difference vector, the information difference vector and a reference to the closest match entry is produced. The compressed data block is characterized as being smaller than the data block.