A bicycle wheel and hub can be configured to provide enhanced stiffness, reduced aerodynamic drag, and reduced weight. For enhanced lateral stiffness, the bicycle wheel comprises a hub having a central body bounded by a first hub flange and a second hub flange. Each of the hub flanges includes a plurality of extensions protruding radially outward from the central body towards a wheel rim. The extensions extend at least one-fifth of the distance from the central body to the rim. A pair of spokes spans between each hub flange extension to the rim. The hub of drive side of a driven wheel may further include a reinforcing member such as a reinforcing ring to accommodate forces and loads imparted by a bicycle drive mechanism. For reduced drag while retaining sufficient lateral stiffness, the central body of the hub may be narrowed and the hub flanges correspondingly repositioned laterally inward.