Compositions that, when used topically in a therapeutically effective amount, are safe and effective for the regression of stratum granulosum in patients exhibiting keratinization disorders, such as psoriasis. The compositions, which can be formulated as ointments, oils, soaps and shampoos, comprise a non-aqueous extract of Wrightia tinctoria, an extract of Cocos nucifera, and pharmaceutically or cosmetically acceptable excipients suitable for topical use.