The present invention relates to alkyl-containing 5-acylindolinones of general formula ##STR00001## wherein R.sup.1 to R.sup.3 are defined herein, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on protein kinases, particularly an inhibiting effect on the activity of glycogen synthase kinase (GSK-3).