Method for Internet Protocol Payload Compression (IPComp) and Large Send is described. More particularly, a Large Send initiated by a computer is used to trigger an IPComp negotiation. After agreement on IPComp, data blocks for such a Large Send are compressed in accordance with an agreed upon compression algorithm prior to being divided up into smaller blocks, such as being divided by a maximum transmission unit, for sending. To further improve performance, a intelligent network interface with Large Send and IPComp capabilities is used for offloading Large Send and IPComp functions.