The present invention provides methods and compositions for the efficient
and enhanced secretion of a protein of interest from a host cell. In
specific, proteins are secreted through the Sec-dependent pathway,
involving the spoIIIJ and/or yqjG gene product(s). In some embodiments,
expression of the spoIIIJ and/or yqjG gene product(s) is modulated by a
promoter operably linked to the gene.