According to one aspect, the present invention is directed to implantable or insertable medical devices which comprise polymeric regions that comprise high vinyl acetate content EVA (or another soft polymer) and a therapeutic agent. In another aspect, the present invention is directed to implantable or insertable medical devices which comprise (a) a first region comprising a first EVA and (b) a second region adjacent to the first region that is of lower durometer than the first region.

 
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